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NORMATEN TABLET 50 MG [SIN07584P]
Active ingredients: NORMATEN TABLET 50 MG
Product Info
NORMATEN TABLET 50 MG
[SIN07584P]
Product information
Active Ingredient and Strength | ATENOLOL - 50 MG |
Dosage Form | TABLET, FILM COATED |
Manufacturer and Country | XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD - MALAYSIA |
Registration Number | SIN07584P |
Licence Holder | APEX PHARMA MARKETING PTE. LTD. |
Forensic Classification | PRESCRIPTION ONLY MEDICINES |
Anatomical Therapeutic Chemical (ATC) code | C07AB03 |
Indications
Normaten is indicated for the control of hypertension and management of angina pectoris. It is also used as oral maintenance therapy for cardiac dysrhythmias after the acute attacks has been controlled by intravenous therapy and for Jong-term prophylaxis of myocardial infarction after recovery.
Dosage and Administration
In adult and children over 12 years:
Hypertension: 50 to 100mg daily as a single dose. The effects will be fully established after 1 to 2 weeks. A further reduction in blood pressure may be achieved by combining Atenolol with other antihypertensive agents.
Angina: 50mg twice daily or 100mg daily once. It is unlikely that the higher dose would be additionally beneficial.
Dysrhythmias: Initially controlled intravenously. Oral maintenance dosage of 50 – 100mg daily, given as a single dose.
Myocardial infarction: In suitable patients, initially controlled intravenously, followed by 50mg Normaten orally, 15 minutes after the intravenous dose, provided no adverse effects occur. This should be followed by a further 50mg orally 12 hours later, then 24 hours later by 100mg orally to be given once daily for up to 10 days. If bradycardia and/or hypotension, or other adverse effects occur, requiring treatment, Normaten should be discontinued.
The elderly: Dosage requirements may be reduced, especially in patients with impaired renal function.
Children: There is no paediatric experience with Atenolol. Atenolol is not recommended for use in children under 12 years of age.
Dosage should be adjusted in patients with severe impairment of renal function as Atenolol is excreted via kidneys.
Table caption
Creatinine clearance: | Dosage: |
>35ml/min/1.73 m2 | no adjustment required |
15 – 35ml/min/1.73 m2 | 50mg daily or 100mg once every two days |
<15ml/min/1.73 m2 | 50mg on alternate days or 100mg once every four days |
Contraindications
It is contraindicated in patients with bronchospasm or obstructive airways disease, metabolic acidosis, sinus bradycardia, or partial heart block (second or third degree heart block). It should not be used in patients with cardiogenic shock and in overt heart failure.
