SODIUM BICARBONATE INTRAVENOUS INFUSION 8.4% W/V [SIN09226P]

Product Info

SODIUM BICARBONATE INTRAVENOUS INFUSION 8.4% W/V

[SIN09226P]

Indications
Correction of metabolic acidosis;
Urine alkalinisation in the case of intoxication with weak organic acids, e.g. barbiturates or acetylsalicylic acid;
Urine alkalinisation in order to improve the solubility of drug substances which are poorly soluble in neutral or acid medium, e.g. methotrexate, sulphonamides;
Urine alkalinisation in the case of haemolysis.

Dosage
The quantity of Sodium Bicarbonate Intravenous Infusion BP to be infused is determined by the blood gas values and is calculated according to the following formulae:
mL of 8.4% w/v Sodium Bicarbonate Intravenous Infusion BP
= negative base excess x kg b.w. x 0.3
(The factor 0.3 corresponds to the proportion of the extracellular fluid in relation to total body fluid).
The maximum daily dose is determined according to the correction requirements.

Correction of metabolic acidosis should not be affected too rapidly. It is advisable to start administering only half of the calculated dose and adjust further doses according to the actual results of blood gas analysis.
Blind buffer therapy is not advisable. It should only be performed in life-threatening situations.

Flow rate
Up to 1.5 mmol of sodium bicarbonate per kg body weight per hour, corresponding to 1.5 ml of 8.4% w/v Sodium Bicarbonate Intravenous Infusion BP/kg bw/h.

Route of administration
Strictly intravenously! 8.4% w/v Sodium Bicarbonate
Intravenous Infusion BP has an osmolarity of about 2000 mOsm/l and, when infused undiluted, it should be administered via central venous catheter, preferably inserted into the vena cava.

Contraindications
Respiratory and metabolic alkalosis,
Hypernatremia,
Hypokalemia.