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NEO-PENOTRAN PESSARY [SIN11180P]

Active ingredients: NEO-PENOTRAN PESSARY

Last updated 26 October 2025

Product Info

NEO-PENOTRAN PESSARY

[SIN11180P]

Product information

Active Ingredient and Strength

METRONIDAZOLE - 500 MG
MICONAZOLE NITRATE - 100 MG

Dosage Form

SUPPOSITORY

Manufacturer and Country

EXELTIS IIAC SAN. VE TIC. A.S. - TURKEY

Registration Number

SIN11180P

Licence Holder

INTEGA PTE LTD

Forensic Classification

PRESCRIPTION ONLY MEDICINES

Anatomical Therapeutic Chemical (ATC) code

G01AF01

Therapeutic indications
It is used in the treatment of candidal vulvovaginitis due to Candida albicans, in bacterial vaginosis due to anaerobic bacteria and Gardnerella vaginalis, in trichomonal vaginitis due to Trichomonas vaginalis and in mixed vaginal infections.

Posology and method of administration
Posology
Do not use without consulting a physician. If it is not advised otherwise by a
physician; One ovule should be inserted at night and in the morning for 7 days.
In recurrent cases, application of one ovule in the morning and one ovule at night for 14 days is recommended. It is not recommended that the administration of NEO-PENOTRAN® in the menstrual period because of the impaired efficacy of the product or facing some difficulties during administration.

Method of administration
Only for intravaginal use.

NEO-PENOTRAN® should be applied in lying position, high into the vagina. Not
to be swallowed or applied by other routes.

Additional information on special populations:

Renal/Liver failure:
In renal failure, the half-life of metronidazole is not changed.

In serious liver function failures, metronidazole clearance may be impaired.
Metronidazole may increase encephalopathy symptoms due to increased
plasma levels and therefore should be used carefully in hepatic encephalopathy
patients.

Paediatric population:
Not recommended for children.

Geriatric population:
Same dose as for adults is administered in elderly over 65 years.

Contraindications
NEO-PENOTRAN® should not be used;

  • In patients known to be hypersensitive to the active ingredients or their derivatives,

  • In patients using alcohol during the treatment or at least 3 days after the treatment,

  • In patients using disulfiram during the treatment or within 2 weeks,

  • During the first trimester of pregnancy,

  • In pregnant women who have trichomonal vaginitis in the first trimester,

  • In cases of porphyria, epilepsy, and serious liver function disorders.