HIDONAC SOLUTION FOR INFUSION 5 G/25 ML [SIN12132P]

Product Info

HIDONAC SOLUTION FOR INFUSION 5 G/25 ML

[SIN12132P]

Therapeutic Indications:
Voluntary or accidental paracetamol poisoning.

Posology and Method of Administration:
To be used only as directed by a medical practitioner. Acetylcysteine should be administered by intravenous infusion preferably using Glucose 5% as the infusion fluid. Sodium Chloride 0.9% may be used if Glucose 5% is not suitable. The full course of treatment with acetylcysteine comprises 3 consecutive intravenous infusions. Doses should be administered sequentially with no break between the infusions. The patient should receive a total dose of 300mg/kg body weight over a 21 hour period.

ADULTS

Administration

• Weigh the patient to determine the correct weight band.

• Use the adult dosage table to determine the appropriate volume of acetylcysteine (ampoule volume) to be added to the infusion fluid for each of the 3 infusion periods.

First infusion
Add the appropriate volume of acetylcysteine injection to 200 mL of infusion fluid and infuse over 1 hour.

Second infusion
Add the appropriate volume of acetylcysteine injection to 500 mL of infusion fluid and infuse over the next 4 hours.

Third infusion
Add the appropriate volume of acetylcysteine injection to 1 litre of infusion fluid and infuse over the next 16 hours.

A ceiling weight of 110 kg should be used when calculating the dosage for obese patients. Dosage should be calculated using the patient’s actual weight.

CHILDREN

Children should be treated with the same doses and regimen as adults. However, the quantity of intravenous fluid used must be modified to take into account age and weight, as fluid overload is a potential danger.

Doses should be administered sequentially using an appropriate intravenous infusion pump.

Preparation and administration of paediatric infusions

• Weigh the child to determine the correct weight band.

• Read off the table the total infusion volume required for each dose according to the weight of the child and make up the solutions according to the directions below.

The full course of treatment with N-acetylcysteine comprises 3 consecutive intravenous infusions.

First infusion
Prepare a 50 mg/mL solution by diluting 10 mL of acetylcysteine (200 mg/mL) with 30 mL glucose 5% or sodium chloride 0.9% to give a total volume of 40 mL.

• Prepare the appropriate volume for the weight of the child.

• The dose is infused over 1 hour at the infusion rate stated in the table.

Second Infusion

• Prepare a 6.25 mg/mL solution by diluting 10 mL of acetylcysteine (200 mg/mL) with 310 mL glucose 5% or sodium chloride 0.9% to give a total volume of 320 mL.

• Prepare the appropriate volume for the weight of the child.

• The dose is infused over 4 hours at the infusion rate stated in the table.

Third Infusion

• Prepare a 6.25 mg/mL solution by diluting 10 mL of acetylcysteine (200 mg/mL) with 310 mL glucose 5% or sodium chloride 0.9% to give a total volume of 320 mL.

• Prepare the appropriate volume for the weight of the child.

• The dose is infused over 16 hours at the infusion rate stated in the table.

For example for a child weighing 12 kg, the first infusion would be 38 mL infused at 38 mL/h over 1 hour, the second infusion would be 100 mL infused at 25 mL/h over 4 hours and the third infusion would be 208 mL infused at 13 mL/h over 16 hours.

Contraindications:
There are no contraindications to the treatment of paracetamol overdose with acetylcysteine.